Late-onset, seropositive, erosive rheumatoid arthritis
Identifieur interne : 002D89 ( Main/Exploration ); précédent : 002D88; suivant : 002D90Late-onset, seropositive, erosive rheumatoid arthritis
Auteurs : Nancy Joseph Lance ; James J. CurranSource :
- Seminars in Arthritis and Rheumatism [ 0049-0172 ] ; 1993.
English descriptors
- KwdEn :
- Teeft :
- Abrupt onset, Aggressive therapy, Arthritis, Arthritis rheum, Clinical features, Complete remissions, Constitutional symptoms, Daily activity, Disease activity, Disease control, Disease duration, Disease onset, Elderly patients, Elderly population, Erosive, Erosive disease, Extraarticular features, Functional class, Functional classification, Functional status, Indolent disease, Indolent onset, Joint count, Lora, Lora patients, Medical center, Morning stiffness, Natural history, Partial remission, Patient population, Polymyalgia rheumatica, Progressive loss, Radiographic changes, Rheum, Rheumatoid, Rheumatoid arthritis, Rheumatoid factor, Secondary sicca syndrome, Secondary syndrome, Sedimentation rate, Seropositive, Side effects, Steinbrocker class, Surgical interventions, Syndrome, Therapeutic response, Younger patients.
Abstract
This report describes the natural history, clinical features, and therapeutic requirements of lateonset seropositive and/or erosive rheumatoid arthritis (LORA). One hundred twenty-nine patients with mean disease duration of 6 years and mean age of disease onset of 66 years were studied. All patients met American Rheumatism Association criteria for rheumatoid arthritis (RA). Ninety-one percent were seropositive for rheumatoid factor, 83% had erosive disease, and 58% had significant medical problems. Therapeutically, most patients required sequential use of multiple second-line agents. Functional classification did not change significantly despite treatment, and complet remissions were unusual even with remittive therapy. It is concluded that a subset of LORA patients have seropositive aggressive, destructive disease.
Url:
DOI: 10.1016/S0049-0172(05)80038-1
Affiliations:
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Curran</name></author></analytic><monogr></monogr><series><title level="j">Seminars in Arthritis and Rheumatism</title><title level="j" type="abbrev">YSARH</title><idno type="ISSN">0049-0172</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="177">177</biblScope><biblScope unit="page" to="182">182</biblScope></imprint><idno type="ISSN">0049-0172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0049-0172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Late-onset rheumatoid arthritis</term><term>elderly</term><term>osseous erosions</term><term>rheumatoid factor</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abrupt onset</term><term>Aggressive therapy</term><term>Arthritis</term><term>Arthritis rheum</term><term>Clinical features</term><term>Complete remissions</term><term>Constitutional symptoms</term><term>Daily activity</term><term>Disease activity</term><term>Disease control</term><term>Disease duration</term><term>Disease onset</term><term>Elderly patients</term><term>Elderly population</term><term>Erosive</term><term>Erosive disease</term><term>Extraarticular features</term><term>Functional class</term><term>Functional classification</term><term>Functional status</term><term>Indolent disease</term><term>Indolent onset</term><term>Joint count</term><term>Lora</term><term>Lora patients</term><term>Medical center</term><term>Morning stiffness</term><term>Natural history</term><term>Partial remission</term><term>Patient population</term><term>Polymyalgia rheumatica</term><term>Progressive loss</term><term>Radiographic changes</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatoid factor</term><term>Secondary sicca syndrome</term><term>Secondary syndrome</term><term>Sedimentation rate</term><term>Seropositive</term><term>Side effects</term><term>Steinbrocker class</term><term>Surgical interventions</term><term>Syndrome</term><term>Therapeutic response</term><term>Younger patients</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report describes the natural history, clinical features, and therapeutic requirements of lateonset seropositive and/or erosive rheumatoid arthritis (LORA). One hundred twenty-nine patients with mean disease duration of 6 years and mean age of disease onset of 66 years were studied. All patients met American Rheumatism Association criteria for rheumatoid arthritis (RA). Ninety-one percent were seropositive for rheumatoid factor, 83% had erosive disease, and 58% had significant medical problems. Therapeutically, most patients required sequential use of multiple second-line agents. Functional classification did not change significantly despite treatment, and complet remissions were unusual even with remittive therapy. It is concluded that a subset of LORA patients have seropositive aggressive, destructive disease.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Curran, James J" sort="Curran, James J" uniqKey="Curran J" first="James J." last="Curran">James J. Curran</name><name sortKey="Lance, Nancy Joseph" sort="Lance, Nancy Joseph" uniqKey="Lance N" first="Nancy Joseph" last="Lance">Nancy Joseph Lance</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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